Top Secret/S.I. was a modern espionage RPG where typically character/agents would go on missions, etc. TSR expanded the line in both historical and futuristic settings with 1930's pulp through Agent 13 and near future tech with F.R.E.E.Lancers, respectively. As a rules supplement it provided TS/SI with low powered super powers that were not too beyond reasonable, not like most comic books. Unlike Agent 13, which was a stand-alone separate setting, F.R.E.E.Lancers was directly tied to the game's ORION vs WEB setting, sort of the next part of that story. It was basically espionage special agents with low leveled super-powers.
From what we've seen, this new show from SyFy, ALPHAS resembles F.R.E.E.Lancers in many ways. It looks like a special S.W.A.T. team of relatively low-powered agents working together on espionage-like missions (what, with sniper rifles and so on). I'd say it would be a ready-made RPG adaptation.